Status:
UNKNOWN
Effectiveness of Acetazolamide in Reducing Paralysis of the Leg in Patients Undergoing Aortic Aneurysm Surgery Surgery
Lead Sponsor:
Liverpool Heart and Chest Hospital NHS Foundation Trust
Conditions:
Thoracic Aneurysm
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The aorta is a large vessel that carries blood away from the heart. Sometimes it becomes dilated (swells) and this is known as 'aneurysm'. It may cause either dissection (splitting of the wall) or rup...
Detailed Description
Aortic aneurysms are classified according to the extent and position of the aorta involved: thoracic aneurysms (TA), include the ascending or descending aorta within the thoracic cavity, thoracic-abdo...
Eligibility Criteria
Inclusion
- Patients who have given consent and are 18+ years old
- Patients who have been able to comply with the pre-operative course of acetazolamide treatment (treatment group) and who have had blood sample collected three days prior to surgery
- Patients with inserted spinal drain
Exclusion
- Non-elective patients, who were not able to participate in pre-operative acetazolamide treatment and blood sample tests three days prior to surgery
- Patients without consent
- Patients in whom a spinal drain could not be positioned
- Patients with blood stained CSF
- Patients who have not adhered to pre-operative course of acetazolamide treatment
- Patients who have had a reaction to the drug, and consequently have had acetazolamide discontinued (but will make note of specific reactions and number of patients involved)
Key Trial Info
Start Date :
July 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2016
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01889498
Start Date
July 1 2014
End Date
June 1 2016
Last Update
December 31 2014
Active Locations (2)
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1
Liverpool heart & chest hospital
Liverpool, United Kingdom, L14 3PE
2
Liverpool Heart & Chest Hospital
Liverpool, United Kingdom, L14 3PE