Status:
COMPLETED
Evaluate the Safety and Efficacy of FG-3019 (Pamrevlumab) in Participants With Idiopathic Pulmonary Fibrosis (IPF)
Lead Sponsor:
FibroGen
Conditions:
Idiopathic Pulmonary Fibrosis
Eligibility:
All Genders
40-80 years
Phase:
PHASE2
Brief Summary
To evaluate the safety and tolerability of pamrevlumab in participants with IPF, and the efficacy of pamrevlumab in slowing the loss of forced vital capacity (FVC) and the progression of IPF in these ...
Detailed Description
The study has been amended in February 2016 to further allow for the enrollment of a subgroup of participants (N=60) who will be allowed to receive treatment with approved IPF therapy with pirfenidone...
Eligibility Criteria
Inclusion
- Age 40 to 80 years, inclusive.
- Diagnosis of IPF as defined by current international guidelines. Each participant must have 1 of the following: (1) Usual Interstitial Pneumonia (UIP) Pattern on an available high-resolution computed tomography (HRCT) scan; or (2) Possible UIP Pattern on an available HRCT scan and surgical lung biopsy within 4 years of Screening showing UIP Pattern.
- History of IPF of ≤5 years duration with onset defined as the date of the first diagnosis of IPF by HRCT or surgical lung biopsy.
- Interstitial pulmonary fibrosis defined by HRCT scan at Screening, with evidence of ≥10% to \<50% parenchymal fibrosis (reticulation) and \<25% honeycombing, within the whole lung, as determined by the HRCT central reader.
- FVC percent of predicted value ≥55% at Screening.
- Female participants of childbearing potential (including those \<1 year postmenopausal) must be willing to use a medically acceptable method of contraception, for example, an oral contraceptive, depot progesterone, or intrauterine device. Male participants with female partners of childbearing potential who are not using birth control as described above must use a barrier method of contraception (for example, condom) if not surgically sterile (for example, vasectomy).
- For sub-study only: Receiving treatment for IPF with a stable dose of pirfenidone or with a stable dose of nintedanib for at least 3 months before Screening initiation and willing to continue treatment with pirfenidone or with nintedanib according to the corresponding approved label and the prescribing physician, including all listed safety requirements (for example, liver function tests, avoidance of sunlight and sunlamp exposure and wearing of sunscreen and protective clothing daily for pirfenidone, and smoking cessation).
Exclusion
- Women who are pregnant or nursing.
- Infiltrative lung disease other than IPF, including any of the other types of idiopathic interstitial pneumonias (Travis, 2013); lung diseases related to exposure to fibrogenic agents or other environmental toxins or drugs; other types of occupational lung diseases; granulomatous lung diseases; pulmonary vascular diseases; systemic diseases, including vasculitis and connective tissue diseases.
- HRCT scan findings at Screening are inconsistent with UIP Pattern, as determined by the HRCT central reader.
- Pathology diagnosis on surgical lung biopsy is anything other than UIP Pattern, as determined by the local pathologist.
- The Investigator judges that there has been sustained improvement in the severity of IPF during the 12 months prior to Screening, based on changes in FVC, diffusing capacity of the lung for carbon monoxide (DLCO), and/or HRCT scans of the chest.
- Clinically important abnormal laboratory tests.
- Upper or lower respiratory tract infection of any type within 4 weeks of the first Screening visit.
- Acute exacerbation of IPF within 3 months of the first Screening visit.
- Use of medications to treat IPF within 5 half-lives of Day 1 dosing. If monoclonal antibodies were used, the last dose of the antibody must be at least 4 weeks before Day 1 dosing. This applies to participants enrolled in Main Study only.
- Use of any investigational drugs, including any investigational drugs for IPF, within 4 weeks prior to Day 1 dosing.
- History of cancer diagnosis of any type in the 3 years preceding Screening, excluding non-melanomatous skin cancer, localized bladder cancer, or in situ cancers.
- Diffusing capacity (DLCO) less than 30% of predicted value.
- History of allergic or anaphylactic reaction to human, humanized, chimeric, or murine monoclonal antibodies.
- Previous treatment with FG-3019.
- Body weight greater than 130 kilograms.
Key Trial Info
Start Date :
July 30 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 16 2017
Estimated Enrollment :
160 Patients enrolled
Trial Details
Trial ID
NCT01890265
Start Date
July 30 2013
End Date
November 16 2017
Last Update
September 4 2020
Active Locations (42)
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1
The Kirklin Clinic
Birmingham, Alabama, United States, 35294
2
David Geffen School of Medicine at UCLA
Los Angeles, California, United States, 90024
3
UC Davis Medical Center
Sacramento, California, United States, 95817
4
National Jewish Health
Denver, Colorado, United States, 80206