Status:
UNKNOWN
Efficacy of Antioxidant Therapy Compared With Enalapril in Sickle Nephropathy
Lead Sponsor:
The University of The West Indies
Collaborating Sponsors:
Caribbean Health Research Council
Conditions:
Microalbuminuria
Sickle Cell Nephropathy
Eligibility:
All Genders
2-18 years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether enalapril or antioxidant therapy (N-Acetylcysteine) is effective in reducing microalbuminuria in children with sickle cell disease and and its progres...
Eligibility Criteria
Inclusion
- Homozygous S sickle cell disease
- Diagnosed by newborn screening
- determined to have persistent microalbuminuria
- satisfied criteria for microalbuminuria screening
- parental consent
Exclusion
- Asymptomatic bacteriuria on screening urine cultures
- On Hydroxyurea therapy
- Pre-existing complications of SCD which would meet local criteria for HU therapy
Key Trial Info
Start Date :
July 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2015
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01891292
Start Date
July 1 2013
End Date
September 1 2015
Last Update
July 3 2013
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Sickle Cell Unit
Kingston, Jamaica