Status:
UNKNOWN
Eplerenone and Aliskiren Research Targeting Hypertensive Patients With Left Ventricular Hypertrophy
Lead Sponsor:
Nagoya University
Conditions:
Hypertensive Left Ventricular Hypertrophy
Eligibility:
All Genders
20-80 years
Phase:
PHASE4
Brief Summary
The primary objective of this study is to determine which treatment will be more effective to reduce left ventricular mass in hypertensive patients with left ventricular hypertrophy comparing aliskire...
Eligibility Criteria
Inclusion
- Male or female ≧ 20 years of age Clinical diagnosis of hypertension Patients who are able to provide written informed consent
Exclusion
- History of congestive heart failure, myocardial infarction, or coronary revascularization in the recent 6 months.
- Planned to taking percutaneous coronary intervention and coronary artery bypass graft
- Severe hypertension (≧ 180/110 mmHg) or secondary hypertension or malignant hypertension.
- History of stroke, cerebral hemorrhage, subarachnoid hemorrhage, transient ischemic attack in the recent 6 months
- Severe valvular heart disease or atrial fibrillation
- Congenital heart disease
- Severe heart failure (NYHA functional class Ⅳ)
- Current treatment with aliskiren or eplerenone or diuretics
- Taking potassium preparation or potassium-sparing diuretic
- Estimated GFR ≦ 30ml/min/1.73m２ at screening or current treatment with hemodialysis
- Potassium \> 5.0mEq/L at screening
- Diabetes mellitus with microalbuminuria or albuminuria
- Impairment of liver function (liver failure, liver cirrhosis)
- Pregnant woman or possibly pregnant woman
- History of malignant tumor include hematological neoplasm
- Current treatment with itraconazole, cyclosporin, ritonavir or nelfinavir
- Prior treatment with, hypersensitivity to, intolerance of or contra-indication to aliskiren and/or eplerenone
- Current participation in another clinical trial
- Serious non-cardiovascular disease severely limiting life expectancy
- Contra-indication to MRI
Key Trial Info
Start Date :
April 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT01893788
Start Date
April 1 2013
Last Update
July 22 2013
Active Locations (1)
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1
Department of Cardiology, Nagoya University Graduate School of Medicine
Nagoya, Aichi-ken, Japan, 466-8550