Status:
COMPLETED
The Effect of Creatine on Muscle Loss
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Muscle Loss
Eligibility:
MALE
18-35 years
Phase:
NA
Brief Summary
The primary aim of this study is to determine the effect of creatine supplementation on muscle mass loss during short-term immobilisation in healthy, young people.
Detailed Description
Seven days of one-legged knee immobilisation in young subjects with creatine or Placebo supplementation. A randomly selected leg is immobilized for seven days. Muscle mass and strength will be determi...
Eligibility Criteria
Inclusion
- Male
- Aged from 18-35 years
- 5 \< BMI \< 30 kg/m2
Exclusion
- (Family) history of thrombosis
- Smoking
- Recent surgery
- Performing regular resistance training more than once per week in the past year
- Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
- Current systemic use of corticosteroids, growth hormone, testosterone, immunosuppressants or insulin
- All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis)
- Use of anti-coagulants
- Pre-existing renal disease or those with a potential risk for renal dysfunction (diabetes, hypertension, reduced glomerular filtration rate)
Key Trial Info
Start Date :
October 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2015
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT01894737
Start Date
October 1 2013
End Date
April 1 2015
Last Update
August 31 2015
Active Locations (1)
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1
Maastricht University Medical Centre+
Maastricht, Limburg, Netherlands, 6200MD