Status:
COMPLETED
Viral Biofilms: Hijacking T Cell Extracellular Matrix to Regulate HIV-1 Spread?
Lead Sponsor:
ANRS, Emerging Infectious Diseases
Conditions:
HIV Infection
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
This project aims at characterizing HIV-1 viral biofilms structural and functional properties and at deciphering its role as a new viral reservoir and as a new mode of viral spread. The prospective na...
Detailed Description
The investigators' preliminary data indicate that besides " free " infectious viral particles, HIV-1 infected cluster of differentiation 4 (CD4+) lymphocytes also produce extracellular viral assemblie...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- able to give written consent
- HIV positive serology HIV1
- Viral load \> 10 000 copies/ml
- CD4 T cells \> 100 cells/mm3
- or Treated by antiretroviral therapy (ARV) for less than 6 months
- Covered by French Social Security
Exclusion
- Involved in a clinical trial
- Pregnancy (inclusion can be postponed)
- No covered by French Social Security
Key Trial Info
Start Date :
January 1 2013
Trial Type :
INTERVENTIONAL
End Date :
February 1 2018
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT01895920
Start Date
January 1 2013
End Date
February 1 2018
Last Update
February 27 2018
Active Locations (1)
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1
Service de Médecine Interne, CHU Kremlin-Bicêtre
Le Kremlin-Bicêtre, France, 94270