Status:
COMPLETED
Urinary Heparanase Activity as a Predictor of Acute Kidney Injury in Critically Ill Adults
Lead Sponsor:
Denver Health and Hospital Authority
Conditions:
Sepsis
Trauma
Eligibility:
All Genders
18+ years
Brief Summary
Across the world, the most common cause of dying in the ICU is a disease called "sepsis". Sepsis is a disease in which the body's protective response to infection becomes too intense, unnecessarily da...
Eligibility Criteria
Inclusion
- 1\. Septic shock or major trauma. Septic shock will be defined by standard criteria including (a) the presence of the systemic inflammatory response syndrome (SIRS), (b) evidence of infection, and (c) treatment with vasopressor medications for \> 4 hours despite \> 30 ml/kg intravenous crystalloid resuscitation. As a critically-ill comparator group, we will also enroll adult patients admitted (within 24 hours prior to screening) to the Denver Health Surgical ICU with major trauma, as defined by an Injury Severity Score of \> 15.
Exclusion
- Exclusion criteria include anuria, prisoners, absence of a routinely-inserted urine collection device, or gross hematuria. Additionally, patients with known genitourinary malignancy will be excluded, given that cancers are known to overexpress heparanase. Additional exclusion criteria include age \< 18 years, and pregnant women.
Key Trial Info
Start Date :
July 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
57 Patients enrolled
Trial Details
Trial ID
NCT01900275
Start Date
July 1 2013
Last Update
November 24 2014
Active Locations (1)
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1
Denver Health Medical Center
Denver, Colorado, United States, 80204