Status:
COMPLETED
Aspirin AM or PM: Effect on Circadian Rhythm of Platelet Reactivity
Lead Sponsor:
Leiden University Medical Center
Conditions:
Aspirin
Circadian Rhythm
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Low-dose aspirin is a cornerstone in the secondary prevention of cardiovascular disease (CVD) and is usually taken on awakening, although evidence regarding optimal time of intake is lacking. Platelet...
Detailed Description
Cardiovascular events are a leading cause of mortality and morbidity in western countries. In the European Union, 47% of total mortality is caused by cardiovascular disease2. Aspirin is a cornerstone ...
Eligibility Criteria
Inclusion
- Healthy subject
- Age \>18yrs
- Capacity to give informed consent (IC)
Exclusion
- Active chronic disease
- Use of any other medication
- History of: major bleeding events, known bleeding diathesis or disorder, cardiovascular disease, malignancy
- Known allergy to salicylates
- Platelet count \< 150 \* 109/L
- VerifyNow Aspirin Reaction Units \<550 Aspirin Reaction Units (ARU)
- Smoking
- Shift work in preceding 2 months
- Extreme chronotypes, defined as regular (\>2 days/week) bedtime \<22:00h or \>24:00h and/or awakening \<6:00h or \>9:00h
- Pregnancy
Key Trial Info
Start Date :
July 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2014
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT01900639
Start Date
July 1 2013
End Date
January 1 2014
Last Update
February 20 2014
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Leiden University Medical Center
Leiden, Netherlands, 2300RC