Status:
COMPLETED
Single-dose, 2-way Crossover Open Study to Evaluate the Food Effect on the PK of HCP1201 in Healthy Volunteers
Lead Sponsor:
Hanmi Pharmaceutical Company Limited
Conditions:
Diabetes Mellitus
Eligibility:
MALE
20-55 years
Phase:
PHASE1
Brief Summary
To investigate the effect of food in healthy male volunteers who receive HCP1201 tablet in fed versus fasted condition
Detailed Description
An open-label, randomized, single-dose crossover study to evaluate the effect of food on the pharmacokinetics of HCP1201 tablet in healthy volunteers
Eligibility Criteria
Inclusion
- Healthy male volunteer, age 20\~55 years
- The result of Body Mass Index(BMI) is not less than 19 kg/m2 , no more than 27 kg/m2
- Subject who has the ability to comprehend the study objectives, contents and the property of the study drug before participating in the trial
- Subject who has the ability and willingness to participate the whole period of trial
Exclusion
- Presence of medical history or a concurrent disease that may interfere with treatment and safety assessment or completion of this clinical study, including clinically significant disorders in kidney, liver, cardiovascular system, respiratory system, endocrine system, or neuropsychiatric system.
- Glomerular filtration rate is under 60ml/min which is calculated by serum creatinine value.
- Liver enzyme (AST, ALT) level exceeds the maximum normal range more than one and a half times.
- Systolic Blood Pressure: lower than 90mmHg or higher than 150mmHg, Diastolic Blood Pressure: lower than 60mmHg or higher than 100mmHg
- History of relevant drug allergies or clinically significant hypersensitivity reaction.
- History of drug abuse or positive drug screening.
- Participation in other drug studies within 60days prior to the drug administration.
- Whole blood donation within 60 days, blood component donation within 30 days or who got transfusion within 30days.
- Subjects who took prescription drugs within 14 days from the patient screening or non-prescription medicine within 7 days which can affect the result of this clinical trial (acceptable according to the investigator's judgement)
- Subjects who took medicines(e.g. proton pump inhibitor, rifampicin, oriental medicines, etc.) within 30days that can affect absorption, distribution, metabolism, elimination of metformin/rosuvastatin.
- Intake of more than 140g of alcohol per week or who can't abstain from alcohol during the trial.
- Subjects who smoke more than 10 cigarettes per day or who can't quit smoking during the trial.
- Positive screening on Hepatitis B surface antigen(HBsAg), anti-Hepatitis C virus(HCV) or anti-Human immunodeficiency virus(HIV).
- Genetic myopathic disorder or related family history, medical history of myopathic disorder caused by medication.
- Clinically inappropriate laboratory test result.
- Clinically inappropriate electrocardiogram result.
- Subjects who judged ineligible by the investigator.
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT01901757
Start Date
June 1 2013
End Date
July 1 2013
Last Update
August 13 2013
Active Locations (1)
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1
Samsung Medical Center
Seoul, South Korea, 135-710