Status:
UNKNOWN
Inhalational Anesthesia and Precipitation of Dementia: is There a Link?
Lead Sponsor:
University Health Network, Toronto
Conditions:
Alzheimer's Disease
Dementia
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
Many elderly patients undergoing surgical procedures already have impaired cognitive (memory/concentration) status. Patients with pre-existing cognitive impairment, or dementia, may benefit from modif...
Eligibility Criteria
Inclusion
- \>65 yrs of age
- Male or female
- Scheduled to undergo urologic procedures (e.g., transurethral resection of prostate, transurethral resection of bladder tumor), orthopedic (e.g., total knee replacement, total hip replacement) general (e.g., femoral hernia repair, lower abdominal surgery) or vascular surgery procedures (e.g. lower limb reperfusion amputations) and qualifies to be randomized to receive either local (spinal) or general anesthetic
Exclusion
- Diagnosis of severe dementia
- Diagnosis of any other significant neurological disease such as Parkinson's, multi-infarct dementia, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma followed by persistent neurologic defaults or known structural brain or spinal abnormalities.
Key Trial Info
Start Date :
March 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2023
Estimated Enrollment :
500 Patients enrolled
Trial Details
Trial ID
NCT01903421
Start Date
March 1 2014
End Date
July 1 2023
Last Update
December 5 2022
Active Locations (3)
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1
Toronto General Hospital, University Health Network
Toronto, Ontario, Canada, M5G 2C4
2
William Osler Health Centre
Toronto, Ontario, Canada, M9V 1R8
3
Pauls Stradins Clinical University Hospital
Riga, Latvia, LV 1002