Status:

COMPLETED

Phase 2 Study to Evaluate LUM001 in Combination With Ursodeoxycholic Acid in Patients With Primary Biliary Cirrhosis

Lead Sponsor:

Mirum Pharmaceuticals, Inc.

Conditions:

PBC

Primary Biliary Cirrhosis

Eligibility:

All Genders

18-80 years

Phase:

PHASE2

Brief Summary

The study is a randomized, double-blind, placebo-controlled, multicenter study. It is a 13-week Phase 2 study in adults with primary biliary cirrhosis designed to compare the effect of daily dosing wi...

Eligibility Criteria

Inclusion

  • Diagnosis of Primary Biliary Cirrhosis
  • Moderate to severe pruritus
  • Taking ursodeoxycholic acid (UDCA) for at least 6 months, or unable to tolerate UDCA
  • Ability to understand and willingness to sign informed consent prior to initiation of any study procedures

Exclusion

  • History or presence of other concomitant significant liver disease
  • Liver transplant
  • Known HIV infection
  • Women who are pregnant or lactating

Key Trial Info

Start Date :

August 1 2013

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

April 1 2015

Estimated Enrollment :

66 Patients enrolled

Trial Details

Trial ID

NCT01904058

Start Date

August 1 2013

End Date

April 1 2015

Last Update

March 27 2019

Active Locations (24)

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Page 1 of 6 (24 locations)

1

Scripps Clinic

La Jolla, California, United States, 92037

2

University of California at Davis

Sacramento, California, United States, 95817

3

University of Miami

Miami, Florida, United States, 33136

4

University of Chicago Medical Center

Chicago, Illinois, United States, 60637

Phase 2 Study to Evaluate LUM001 in Combination With Ursodeoxycholic Acid in Patients With Primary Biliary Cirrhosis | DecenTrialz