Status:
TERMINATED
Moderate Intensity Exercise and Phenylketonuria
Lead Sponsor:
Oregon Health and Science University
Conditions:
Phenylketonuria
PKU
Eligibility:
MALE
14-17 years
Phase:
NA
Brief Summary
Phenylketonuria (PKU), an inherited genetic disorder, can cause irreversible brain damage, declined executive function, and autistic tendencies unless a phenylalanine (Phe) restricted diet is consiste...
Detailed Description
The indicator amino acid oxidation technique utilizes a carbon labeled isotope (L-\[13C\]) tracer that is ingested orally and is measured in expired breath. This method is based on the theory that if ...
Eligibility Criteria
Inclusion
- plasma phenylalanine concentration of \>1200 micromols at diagnosis
- treated by dietary phenylalanine restriction from early infancy
- willing to participate in this study
- stable BMI of 20-25 for the past 3 months
- currently in average to good physical fitness condition
- physically active 3-4 days per week
Exclusion
- previously or are currently taking approved or experimental pharmacologic treatments (i.e.: Biopterin (BH4), sapropterin dihydrochloride (Kuvan), Large Neutral Amino Acids (LNAA), pegylated phenylalanine ammonia lyase (PEG-PAL))
- recent history of weight loss
- endocrine disorder
- pregnant
- anemic
- involved in any other study or research protocol
- participation in a current strength training or performance training regimen
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
2 Patients enrolled
Trial Details
Trial ID
NCT01904708
Start Date
May 1 2013
End Date
June 1 2014
Last Update
October 16 2014
Active Locations (1)
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1
Oregon Health and Science University
Portland, Oregon, United States, 97239