Status:
UNKNOWN
The Optimal Timing Of Primaquine To Prevent Malaria Transmission After Artemisinin-Combination Therapy
Lead Sponsor:
Kilimanjaro Clinical Research Institute
Collaborating Sponsors:
London School of Hygiene and Tropical Medicine
Ifakara Health Institute
Conditions:
Malaria Transmission
Eligibility:
All Genders
3-17 years
Phase:
PHASE4
Brief Summary
The investigators' Hypothesis is that "The correct timing of gametocytocidal drug in combination with an effective Artemisinin Combination Therapy can limit the infectiousness of malaria-infected indi...
Detailed Description
Global malaria elimination is back on the agenda, gametocytocidal drugs such as primaquine are currently advocated for use in the interventions that aim to interrupt malaria transmission and hence eli...
Eligibility Criteria
Inclusion
- Age 3 years - 17 years
- Residents of research area
- Willingness to come for complete scheduled follow-up.
- Uncomplicated malaria with P. falciparum mono-infection
- Axillary temperature \> 37.5°C and \< 39.5°C, or history of fever in previous 48 hours.
- No history of adverse reactions to study medication
- Understanding of the procedures of the study by parent or guardian and willing to participate by signing written informed consent forms
Exclusion
- Haemoglobin below 9g/dl
- Inability to take drugs orally
- Known hypersensitivity to any of the drugs given
- Reported treatment with antimalarial chemotherapy in the past 2 weeks
- Evidence of chronic disease or acute infection other than malaria
- Domicile outside the study area
- Signs of severe malaria( such as respiratory distress, altered consciousness deep breathing, anaemia)
- Participating in other malaria studies conducted in the region
- Mixed malaria parasite species infection
- Positive pregnant test by Urine (UPT) if participant is female aged above 12 years
- G6PD deficient using the fluorescence spot test
Key Trial Info
Start Date :
May 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2013
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT01906788
Start Date
May 1 2013
End Date
October 1 2013
Last Update
July 24 2013
Active Locations (1)
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1
Bagamoyo Research and Training Centre
Bagamoyo, Tanzania