Status:
COMPLETED
Comparison of Diltiazem and Metoprolol in the Management of Acute Atrial Fibrillation or Atrial Flutter
Lead Sponsor:
Antonios Likourezos
Conditions:
Heart Rate and Rhythm Disorders
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Acute atrial fibrillation is the most common sustained, clinically significant dysrhythmia encountered in the emergency department (ED) and the most common dysrhythmia treated by emergency physicians....
Detailed Description
We conducted a prospective, randomized, double-blind study to compare the effectiveness of intravenous metoprolol with that of diltiazem in achieving rate control in adult ED patients with rapid atria...
Eligibility Criteria
Inclusion
- Eligible patients had to have a 12-lead electrocardiogram (ECG) showing atrial fibrillation or atrial flutter with a ventricular rate of greater than or equal to 120 beats per minute and a systolic blood pressure of greater than or equal to 90 mmHg.
Exclusion
- Patients were excluded if they had any of the following:
- a systolic blood pressure \<90 mmHg, ventricular rate greater than or equal to 220 beats per minute,
- QRS \>0.100 seconds, 2nd or 3rd degree atrioventricular (AV) block,
- temperature \>38.0 ˚C,
- acute ST elevation myocardial infarction,
- known history of New York Heart Association Class IV heart failure or
- active wheezing with a history of bronchial asthma or COPD.
- In addition, patients were excluded if there was:
- prehospital administration of diltiazem or any other AV nodal blockading agent,
- a history of cocaine or methamphetamine use in the previous 24 hours prior to arrival,
- a history of allergic reaction to diltiazem or metoprolol,
- a history of sick sinus or pre-excitation syndromes,
- a history of anemia with hemoglobin \<11.0 g/dl,
- pregnancy or breastfeeding.
Key Trial Info
Start Date :
June 1 2009
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2010
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT01914926
Start Date
June 1 2009
End Date
November 1 2010
Last Update
May 15 2014
Active Locations (1)
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1
Maimonides Medical Center
Brooklyn, New York, United States, 11219