Status:
COMPLETED
Improving Motor Function After Spinal Cord Injury
Lead Sponsor:
VA Office of Research and Development
Conditions:
Spinal Cord Injury
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
The goals of this study are to examine the physiology of Central Nervous System pathways contributing to the control of upper and lower extremity movements after SCI, and to promote the recovery of ex...
Detailed Description
This study will consist of electromyography (surface and intramuscular), peripheral nerve stimulation, and transcranial magnetic stimulation, electrical stimulation, of the hand, arm, leg, and foot re...
Eligibility Criteria
Inclusion
- Male and female Veterans and non Veterans with spinal cord injury at least 6 months after injury was sustained. The investigators also plan to enroll control subjects who do not have any history of spinal cord injury.
- Participants who are unimpaired healthy controls:
- Male and females between ages 18-85 years
- Right handed
- Able to complete precision grips with both hands
- Able to complete full wrist flexion-extension bilaterally
- Able to walk unassisted
- Able to complete full ankle flexion-extension bilaterally
- Participants who have had a spinal cord injury:
- Male and females between ages 18-85 years
- Chronic SCI ( 6 months of injury)
- Spinal Cord injury at or above L5
- The ability to produce a visible precision grip force with one hand
- Individuals who have the ability to pick up a small object (large paperclip) from a table independently
- Able to perform some small wrist flexion and extension (measured by a goniometer)
- The ability to perform a small visible contraction with dorsiflexor and hip flexor muscles
- No subjects will be excluded based on their race, religion, ethnicity, gender or HIV status.
Exclusion
- Exclusion criteria for enrollment For SCI and Healthy Control Subjects (for stimulation):
- Uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease
- Any debilitating disease prior to the SCI that caused exercise intolerance
- Premorbid, ongoing major depression or psychosis, altered cognitive status
- History of head injury or stroke
- Metal plate in skull
- History of seizures
- Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold (see appendix 2)
- Pregnant females
- Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida, MS, or herniated cervical disk
- Individuals with scalp shrapnel, cochlear implants, or aneurysm clips.
Key Trial Info
Start Date :
September 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2019
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT01915095
Start Date
September 1 2017
End Date
September 1 2019
Last Update
June 11 2021
Active Locations (3)
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1
Miami VA Healthcare System, Miami, FL
Miami, Florida, United States, 33125
2
Edward Hines Jr. VA Hospital, Hines, IL
Hines, Illinois, United States, 60141-5000
3
VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA
Pittsburgh, Pennsylvania, United States, 15240