Status:
COMPLETED
Effects of Treatment on Decision-making in Major Depression
Lead Sponsor:
Emory University
Conditions:
Major Depressive Disorder
Healthy Controls
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
In this trial, fifty participants with current major depressive disorder who are not receiving an antidepressant medication and fifty healthy controls will complete questionnaires and computerized tas...
Detailed Description
During episodes of depression patients with major depressive disorder (MDD) may make sub-optimal decisions based on exaggerated negative beliefs about themselves, the future, or the world around them....
Eligibility Criteria
Inclusion
- Inclusion Criteria for MDD Subjects:
- Male or female, age 18-65
- Primary Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV TR) Diagnosis of Major Depressive Disorder.
- Has a 17-item Hamilton depression rating scale (HDRS-17) score \>=16.
- Ability to visually read and understand English language
- Not currently taking an antidepressant.
- Women of reproductive potential must be willing to take a medically approved form of birth control throughout the duration of the study.
- Inclusion Criteria for Healthy Control Subjects:
- Male or female, age 18-65
- No current DSM-IV TR diagnosis of a mental illness.
- No lifetime history of Major Depressive Disorder or Dysthymia.
- Has a 17-item Hamilton depression rating scale (HDRS-17) score ≤7.
- Ability to visually read and understand English language
- Not currently taking any psychoactive medication
- Exclusion Criteria for all subjects:
- Has met criteria at any time during their life for bipolar disorder, a primary psychotic disorder (e.g. schizophrenia), or dementia.
- Meet criteria for substance abuse or dependence within three months of the screening visit.
- Presents with a clinically significant suicide risk, as assessed by a study physician.
- Presence of any unstable or central nervous system-related medical illness that would interfere with cognition or participation.
- Women who are currently pregnant or lactating, or plan to become pregnant during the study.
Exclusion
Key Trial Info
Start Date :
August 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT01916824
Start Date
August 1 2013
End Date
December 1 2015
Last Update
November 21 2017
Active Locations (1)
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1
Emory Mood and Anxiety Disorders Program
Atlanta, Georgia, United States, 30322