Status:
COMPLETED
Neural Mechanisms of Change During the Treatment of Alcohol Use Disorders With Prazosin
Lead Sponsor:
University of New Mexico
Conditions:
Alcohol Use Disorder
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The study uses neurobiological measures through brain imaging, neuropsychological measures, and selfreport measures to try to understand how an effective treatment for alcoholism works. On the whole, ...
Eligibility Criteria
Inclusion
- Males and females age 18-65 meeting DSM-IV criteria for alcohol dependence in the past year;
- seeking but not currently receiving treatment;
- able to provide voluntary informed consent;
- have at least 4 drinking days in the past 30 days
- english-speaking
- have a primary care physician or psychiatrist willing to continue prazosin if the patient tolerates it well and is finding it beneficial.
Exclusion
- severe neurological (e.g., head injury/stroke) conditions, Meniere's disease, narcolepsy, benign positional vertigo, heart disease or unstable angina, history of dysrhythmia/syncope, SBP\<110, SBP\>160, DBP\>110, HR\<55, HR\>110, irregular heart rhythm, chronic renal or hepatic failure, pancreatitis or insulin-dependent diabetes, or other medical problems requiring immediate attention;
- schizophrenia, schizoaffective disorder, PTSD, Bipolar I disorder, suicidal thoughts within the last month;
- current dependence on another drug of abuse (except nicotine);
- contraindications to MRI (e.g., pacemaker);
- active legal problems with the potential to result in incarceration;
- pregnancy or lactation, or child bearing age and not on birth control;
- currently receiving treatment for alcohol dependence;
- current use of psychoactive medications including SSRI's and other antidepressants, anti-craving medications, anxiolytics including benzodiazepines, antipsychotics, mood stabilizers or anticonvulsants;
- history of seizures or DT's during alcohol withdrawal.
Key Trial Info
Start Date :
September 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2017
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT01916941
Start Date
September 1 2013
End Date
September 1 2017
Last Update
October 17 2017
Active Locations (1)
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1
University of New Mexico, Department of Psychiatry
Albuquerque, New Mexico, United States, 87031