Status:
COMPLETED
A Safety and Efficacy Study of Oral Prolonged-Release Fampridine (BIIB041) in Japanese Participants With Multiple Sclerosis
Lead Sponsor:
Biogen
Conditions:
Multiple Sclerosis, Remittent Progressive
Multiple Sclerosis, Primary Progressive
Eligibility:
All Genders
18-70 years
Phase:
PHASE3
Brief Summary
This is a multicenter study conducted in 3 parts. Part A is a double-blind placebo-controlled parallel-group period, and Part B and C are open-label extension periods. The primary objective of the dou...
Eligibility Criteria
Inclusion
- Key
- Part A
- To be eligible to participate in Part A, candidates must meet the following eligibility criteria at screening or at the timepoint specified in the individual eligibility criterion listed (potential subjects who fail screening may be rescreened 1 time):
- Must have a diagnosis of primary-progressive, secondary progressive, progressive relapsing, or relapsing-remitting MS as defined by the revised McDonald Committee criteria (\[Lublin and Reingold 1996; McDonald 2001; Polman 2005\]) of at least 2 months duration.
- Must be able to complete the T25FW with or without a walking aid in 8 to 45 seconds at the screening visit.
- Part B
- To be eligible to participate in Part B, candidates must meet the following criteria at the Week 21 visit in Part A, which is the first visit for Part B:
- 1\. Completed all visits in Part A of the study.
- Part C
- To be eligible to participate in Part C, candidates must meet the following criteria at the Week 52 visit in Part B, which is the first visit for Part C:
- 1\. Completed all visits in Part B of the study.
- Key
Exclusion
- Known allergy to pyridine-containing substances, or any of the inactive ingredients of the prolonged-release fampridine tablet
- Any prior history of seizures, epilepsy, or other convulsive disorder, with the exception of febrile seizures in childhood, or prior history of epileptiform activity on electroencephalogram.
- Any form of renal impairment as defined by a creatinine clearance (CrCl) of \<80 mL/min (estimated by the central laboratory).
- Known history of cardiac arrhythmia or cardiac conduction disorders requiring medical or surgical intervention, or any clinically significant ECG abnormality (as determined by the Investigator) at the screening visit or Day 1.
- Any prior treatment with fampridine (4 AP) or 3,4 diaminopyridine in any formulation.
- Treatment with an investigational drug or approved therapy for investigational use within 30 days (or 5 half lives, whichever is longer) prior to the screening visit.
- Participation in an investigational study (with the exception of observational studies) within 30 days prior to the screening visit or plans to enroll in another interventional investigational study at any time during this study.
- NOTE: Other protocol defined Inclusion/Exclusion criteria may apply.
Key Trial Info
Start Date :
August 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2017
Estimated Enrollment :
101 Patients enrolled
Trial Details
Trial ID
NCT01917019
Start Date
August 1 2013
End Date
March 1 2017
Last Update
March 21 2017
Active Locations (19)
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1
Research Site
Bunkyō City, Japan
2
Research Site
Chiba, Japan
3
Research Site
Fuchū, Japan
4
Research Site
Fukuoka, Japan