Status:
COMPLETED
Impact of Periodontal Intervention on Vascular Dysfunction
Lead Sponsor:
First Affiliated Hospital, Sun Yat-Sen University
Conditions:
Chronic Periodontitis
Prehypertension
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine the effect of periodontal intervention on vascular dysfunction among Chinese prehypertensive adults with moderate to severe periodontal disease.
Detailed Description
Periodontitis is one of the low-grade chronic diseases, and it is the principal cause of tooth loss among middle-aged and elderly. Recently, epidemiological data indicate that patients with periodonti...
Eligibility Criteria
Inclusion
- Subjects must be 18 years of age or older
- Moderate to severe generalized periodontitis(probing pocket depths of \>6 mm and Marginal alveolar bone loss of \>30%) with 50% or more of their teeth affected
- Have at least 16 natural teeth excluding third molars
- BPs ranging from 120 to 139 mm Hg systolic and/or 80 to 89 mm Hg diastolic blood pressure
- Provide informed consent and willingness to cooperate with the study protocol
Exclusion
- History of antibiotic use in the previous three months
- Pregnant or lactating females
- Systemic diseases such as diabetes, HIV/AIDS, liver disease, chronic renal failure, tuberculosis, and autoimmune diseases
- Medical history of cardiovascular disease: Acute myocardial infarct, stable angina, unstable angina, heart failure, atrial fibrillation, atrioventricular blockade, peripheral vascular disease, cerebrovascular accident, hypertension
- Patients who received periodontal treatment within the last 6 months
- Patients who require antibiotic prophylaxis before examination or treatment
- Patients with mental retardation and dementia
Key Trial Info
Start Date :
December 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2014
Estimated Enrollment :
123 Patients enrolled
Trial Details
Trial ID
NCT01917292
Start Date
December 1 2012
End Date
June 1 2014
Last Update
April 17 2015
Active Locations (1)
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1
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China, 510080