Status:
COMPLETED
Protective Immune Mechanisms in Alcoholic Hepatitis
Lead Sponsor:
University of Aarhus
Conditions:
Alcoholic Hepatitis
Eligibility:
All Genders
18-69 years
Brief Summary
The purpose of this study is to investigate the production, effects and interactions of the hepato-protective cytokine interleukine (IL)-22 in patients with alcoholic hepatitis.
Detailed Description
The investigators will study hepatic biopsies from patients with alcoholic hepatitis. In these biopsies, the investigators will assess the production of IL-22 and which cells produce the cytokine. The...
Eligibility Criteria
Inclusion
- Diagnosis of alcoholic hepatitis:
- relevant history of alcohol consumption (\>40g/day for a minimum of 6 months with cessation of consumption no earlier than 3 months prior to admission)
- bilirubin \> 80 mol/l
- neutrophil granulocytes \> 10x10\^9/L
- exclusion of other liver pathology including biliary disease
- histological verification on liver biopsy
- Written, informed consent
Exclusion
- Other chronic inflammatory or autoimmune diseases
- Severe, acute bacterial infection (peritonitis, sepsis, pneumonia, urinary tract infection etc.)
- Cancer
- Prednisolon or pentoxifylline treatment within the past 8 weeks
- Pregnancy
Key Trial Info
Start Date :
April 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 20 2018
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT01918462
Start Date
April 1 2013
End Date
April 20 2018
Last Update
April 29 2021
Active Locations (1)
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1
Department of Hepatology and gastroenterology V, Aarhus university hospital
Aarhus, Denmark, 8000