Status:
COMPLETED
Muscle Afferent Feedback Effects in Patients With Heart Failure
Lead Sponsor:
University of Utah
Conditions:
Chronic Heart Failure
Eligibility:
All Genders
20-79 years
Phase:
PHASE1
Brief Summary
The purpose of the study is to find out more about the mechanism by which neural feedback from the working muscle affects the development of central fatigue during exercise. Subjects with chronic hear...
Detailed Description
A substantial part in limiting exercise and/or physical activity in humans results from the development of peripheral and central fatigue during physical activity. Peripheral fatigue comprises biochem...
Eligibility Criteria
Inclusion
- Heart Failure
- Subjects with a history of stable cardiomyopathy (ischemic and non-ischemic, greater than 1 year duration, ages 20-79 years)
- New York Heart Association class I through IV symptoms
- Left ventricular ejection fraction less than 35 percent (heart failure patients with reduced left ventricular ejection fraction) or greater than 50 percent (heart failure patients with preserved left ventricular ejection fraction)
- Sedentary, no regular physical activity for at least 6 months prior
- Post-menopausal for at least 2 years and follicle stimulating hormone greater than 40
- Heart Failure
Exclusion
- Patients with atrial fibrillation or heart failure believed to be secondary to atrial fibrillation
- Morbidly obese patients with a body mass index greater than 35
- Patients with uncontrolled hypertension, greater than 160/100
- Anemia with a hemoglobin less than 9
- Severe renal insufficiency (creatinine clearance less than 30 by the Cockcroft-Gault formula)
- Patients with significant non-cardiac comorbidities
- Orthopedic limitations that would prohibit them from performing the elbow-flexor exercise
- Current smoker or smoking history of 15 packs or more per year
- Women currently taking hormone replacement therapy
- Healthy Control Inclusion Criteria:
- Ages 20-75 years
- Sedentary, no regular physical activity for at least 6 months prior
- Post-menopausal for at least 2 years and follicle stimulating hormone greater than 40
- Healthy Control
Key Trial Info
Start Date :
September 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 3 2018
Estimated Enrollment :
144 Patients enrolled
Trial Details
Trial ID
NCT01919918
Start Date
September 1 2013
End Date
January 3 2018
Last Update
January 8 2018
Active Locations (2)
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1
George E Wahlen Vetern Affairs Medical Center
Salt Lake City, Utah, United States, 84148
2
Veterans Affairs Salt Lake City Heath Care System
Salt Lake City, Utah, United States, 84148