Status:
UNKNOWN
Low-dose Dexamethasone in Newly Diagnosed Pulmonary Sarcoidosis
Lead Sponsor:
St. Antonius Hospital
Conditions:
Sarcoidosis
Eligibility:
All Genders
18-60 years
Phase:
PHASE3
Brief Summary
This trial examines whether low grade suppression of the initial inflammatory process of sarcoidosis by intervention with low-dose dexamethasone therapy achieves significant alleviation of (sub-)acute...
Detailed Description
The orphan disease sarcoidosis causes a major reduction in quality of life and loss of work productivity, especially in young adults. Most patients are diagnosed between the age of 20-40 years. In sar...
Eligibility Criteria
Inclusion
- Diagnosis of sarcoidosis, confirmed by histology or cytology
- Age 18-60 years
- No affected organ requiring high dose immunosuppressive therapy
- Short Form - 36 subscale physical functioning score \< 70 points
Exclusion
- Allergy to corticosteroids
- Diagnosis of glaucoma, osteoporosis, history of fractures
- History of gastric ulcera in the past 12 months
- Current use of Non Steroidal Anti Inflammatory Drug without co-prescription of Proton Pump Inhibitor
- Current use of carbamazepin, fenytoin, rifampicin
- Obesity (BMI \> 30)
- Pregnancy of lactation
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
76 Patients enrolled
Trial Details
Trial ID
NCT01920919
Start Date
June 1 2013
Last Update
November 19 2014
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
St Antonius Hospital
Nieuwegein, Netherlands, 3430 EM