Status:
COMPLETED
Maximal Stimulation and Delayed Fertilization for Diminished Ovarian Reserve: a Randomized Pilot Study
Lead Sponsor:
Wake Forest University Health Sciences
Conditions:
Infertility
Eligibility:
FEMALE
18+ years
Phase:
PHASE4
Brief Summary
The purpose of the study is (A) to determine if the following novel approach improves the live birth rate with In-Vitro Fertilization (IVF) for women with a poor prognosis due to diminished ovarian re...
Detailed Description
Women who are not eligible to participate in the CMC Assisted Reproductive Therapy (ART) program because of an extremely poor prognosis will be recruited for a prospective, randomized, open-label stud...
Eligibility Criteria
Inclusion
- Basal FSH 17 IU/mL (highest ever)
- Basal FSH 15-17 (highest ever) and failed EFORT test
- Age \> 43 at the time of expected retrieval
- Failure to conceive with a prior "poor prognosis" IVF stimulation protocol (microdose leuprolide flare or GnRH antagonist cycle) if administered because of evidence of diminished ovarian reserve
- Failure to conceive with 3 or more IVF cycles at CMC
Exclusion
- Contraindications to IVF
- Contraindication to pregnancy
- Allergy or contraindication to medications used for IVF or embryo transfer
- Use for a gestational carrier
- Uncorrected or untreatable uterine infertility
- Smoking or substance abuse within 3 months of initiating stimulation for IVF
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2014
Estimated Enrollment :
23 Patients enrolled
Trial Details
Trial ID
NCT01921166
Start Date
January 1 2011
End Date
March 1 2014
Last Update
August 2 2024
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