Status:
COMPLETED
Respiratory Kinematics of Cough in Healthy Older Adults and Parkinson's Disease
Lead Sponsor:
University of Florida
Conditions:
Cough
Parkinson's Disease
Eligibility:
All Genders
55-85 years
Phase:
PHASE1
PHASE2
Brief Summary
The purpose of this research study is to test cough function in individuals with Parkinson's disease and healthy older adults. Cough is a complex, defensive function which involves movement of the che...
Detailed Description
If the participant agrees to participate, the investigators will first test pulmonary (lung) function. Next, the investigators will test voluntary and reflex cough. After this first round of cough tes...
Eligibility Criteria
Inclusion
- Age 55-85 years
- Ability to provide informed consent
- For participants with Parkinson's disease (PD):
- \- Diagnosis of PD (Hoehn \& Yahr stages II-IV) by a University of Florida Movement Disorders fellowship trained neurologist having completed a clinical assessment of each participant's PD severity and arriving at the diagnosis of PD by applying strict United Kingdom brain bank criteria.
Exclusion
- Participants with PD:
- \- History of neurological disorders other than PD (e.g. multiple sclerosis, stroke, brain tumor, etc)
- Healthy older adults:
- History of neurological disease including PD
- History of head and neck cancer
- History of breathing disorders or disease (i.e. chronic obstructive pulmonary disease, asthma)
- History of smoking for more than 5 years at any one time (as this reduces the sensitivity to capsaicin)
- History of chest infection the last 5 weeks
- Failure of a screening test of pulmonary function (e.g. forced expiratory volume in one second/forced vital capacity\<75%)
- Difficulty complying due to neuropsychological dysfunction (i.e. severe depression)
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT02183519
Start Date
October 1 2014
End Date
August 1 2015
Last Update
March 24 2017
Active Locations (2)
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1
Center for Movement Disorders and Neurorestoration
Gainesville, Florida, United States, 32611
2
Dauer Hall, University of Florida
Gainesville, Florida, United States, 32611