Status:
UNKNOWN
Laparoscopic Microwave Ablation and Portal Vein Ligation for Staged Hepatectomy (LAPS)
Lead Sponsor:
Azienda Ospedaliera di Padova
Conditions:
Liver Tumors
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
One of the limiting factors in the execution of a liver resection, in particular an extended liver resection, it's represented by the future remnant liver (FRL) after hepatic surgery. In cases of norm...
Detailed Description
In patients with primary or metastatic liver tumors, the only potentially curative therapeutic option is represented by hepatic resection. Nowdays extended resections can be performed with acceptable ...
Eligibility Criteria
Inclusion
- Patients aged between 18 and 70 years (M and F)
- Liver tumors that interests the right hepatic lobe (segments 4,5,6,7,8) with possible involvement of the caudate lobe (segment 1) or bilobar disease with less than 3 lesions in the left lateral lobe without vascular involvement and amenable to surgically resectable or ablation in the Step1.
- Absence of extrahepatic disease
- Normal hepatic function (total bilirubin \<3 mg / dL)
- Performance status: ECOG 0
- In case of liver cirrhosis MELD score \<9
- Patients without prior chemotherapy or with previous chemotherapy but with response disease
- Patients who give their consent to the intervention
Exclusion
- CT Evidence of involvement of the major vessels in the future remnant liver
- Presence of more than 3 nodules in the left lateral lobe
- Presence of extrahepatic disease
- Severe hepatic impairment
- Age\> 70 years
- Previous liver surgery (prior liver resections)
- Patient receiving chemotherapy with documented disease progression
Key Trial Info
Start Date :
June 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2017
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT02184182
Start Date
June 1 2014
End Date
June 1 2017
Last Update
July 9 2014
Active Locations (1)
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1
Chirurgia Epatobiliare e Trapianto Epatico - Azienda Ospedaliera di Padova
Padua, Padova, Italy, 35100