Status:
COMPLETED
Pre-hospital Anti-fibrinolytics for Traumatic Coagulopathy and Haemorrhage (The PATCH Study)
Lead Sponsor:
Monash University
Collaborating Sponsors:
National Health and Medical Research Council, Australia
Health Research Council, New Zealand
Conditions:
Wounds and Injuries
Acute Coagulopathy
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this research is to determine whether giving severely injured adults a drug called tranexamic acid (TXA) as soon as possible after injury will improve their chances of survival and thei...
Eligibility Criteria
Inclusion
- Adult patients (estimated age 18 years or older)
- Injured through any mechanism
- Coagulopathy of severe trauma (COAST) score of 3 points or greater
- First dose of study drug can be administered within three hours of injury
- Patients to be transported to a participating trauma centre
- COAST score
- Entrapment (ie in vehicle) \[Yes = 1, No = 0\]
- Systolic blood pressure \[\<90 mmHg = 2, \<100 mmHg = 1, ≥100 mmHg = 0\]
- Temperature \[\<32℃ =2, \<35℃ = 1, ≥35℃ = 0\]
- Major chest injury likely to require intervention (e.g. decompression, chest tube) \[Yes = 1, No = 0\]
- Likely intra-abdominal or pelvic injury \[Yes = 1, No = 0\]
Exclusion
- Suspected pregnancy
- Nursing home residents
Key Trial Info
Start Date :
July 28 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 7 2022
Estimated Enrollment :
1310 Patients enrolled
Trial Details
Trial ID
NCT02187120
Start Date
July 28 2014
End Date
September 7 2022
Last Update
January 27 2023
Active Locations (33)
Enter a location and click search to find clinical trials sorted by distance.
1
Lismore Base Hospital
Lismore, New South Wales, Australia, 2480
2
NNSW Medical Retrieval Service
Lismore, New South Wales, Australia, 2480
3
John Hunter Hospital
Newcastle, New South Wales, Australia, 2305
4
CareFlight
Northmead, New South Wales, Australia, 2152