Status:
COMPLETED
The Predictive Factors of Good Clinical Response to Cholinesterase Inhibitors in Alzheimer Disease and Mixed Dementia
Lead Sponsor:
Federal University of Minas Gerais
Conditions:
Alzheimer Disease, Late Onset
Eligibility:
All Genders
59-92 years
Brief Summary
Background and objectives: The aims of this naturalistic study were: to analyze factors which could be predictive of good response to cholinesterase inhibitors (ChEI), such as: age, sex, schooling, mi...
Detailed Description
Genomic DNA for genotyping was extracted from total blood samples collected in ethylenediaminetetraacetic acid (EDTA) (Wizard Genomic DNA Purification Kit: Promega®, USA) and kept frozen at seventy de...
Eligibility Criteria
Inclusion
- \- AD diagnosis or AD with CVD according the criteria of National Institute on Aging and the Alzheimer's Association workgroup and the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA)
Exclusion
- Patients with mild cognitive impairment;
- Other types of dementia, such as pure vascular dementia, frontotemporal dementia, dementia with Lewy bodies, corticobasal degeneration;
- Severe dementia (CDR 3)
- Those who were already taking ChEI,
- If there have not been agreement between the first researcher and the treating physician.
Key Trial Info
Start Date :
June 1 2009
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 1 2013
Estimated Enrollment :
129 Patients enrolled
Trial Details
Trial ID
NCT02187276
Start Date
June 1 2009
End Date
March 1 2013
Last Update
September 12 2014
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