Status:
COMPLETED
Inflammation After One Lung Ventilation
Lead Sponsor:
University Medical Centre Ljubljana
Conditions:
Inflammation
Eligibility:
All Genders
20-70 years
Phase:
PHASE1
Brief Summary
The aim of the study was to prospectively investigate the influence of one-lung ventilation (OLV) on the inflammatory response and to identify possible antiinflammatory effects of the volatile anaesth...
Detailed Description
Lung injury is the main complication of open lung surgery and is associated with a very high mortality rate. In 1984, Zeldin reported on ten patients with a complication that he referred to as postpn...
Eligibility Criteria
Inclusion
- Patients aged 20-70 years
- American Society of Anaesthesiologists (ASA) physical status I-III
- elective open lobectomy with OLV
Exclusion
- history of drug hypersensitivity
- drug addiction
- treatment with psychotropic drugs
- severe psychiatric and central nerve system diseases
- persistent tobacco abuse, autoimmune system diseases
- diabetes mellitus
- cardiac failure (New York Heart Association class greater than 2)
- clinically relevant obstructive and restrictive lung diseases (vital capacity or forced expiratory volume in 1s lover than 50% of the predicted values)
- pulmonary hypertension (mean pulmonary arterial pressure grater than 25 mmHg)
- pre-existing coagulation disorders
- history of treatment with immunosuppressant drugs in the 4 weeks before surgery
- Patient with evidence of pulmonary or systemic infections (C-reactive protein serum concentration greater than 5 mg/L, leucocytosis greater than 10.0 bioparticles/L or body temperature greater than 37 stC)
- perioperative blood derivatives, steroids or non-steroidal anti-inflammatory drug (NSAID)
Key Trial Info
Start Date :
July 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2014
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT02188407
Start Date
July 1 2008
End Date
January 1 2014
Last Update
July 11 2014
Active Locations (1)
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1
UMCLjubljana, CD of Anaesthesiology and Intensive Therapy
Ljubljana, Slovenia, 1230