Status:
TERMINATED
Effects of Electronic Cigarettes on Lung Biology
Lead Sponsor:
Weill Medical College of Cornell University
Conditions:
Lung Disease
Lung Disorder
Eligibility:
All Genders
21-85 years
Phase:
NA
Brief Summary
E-cigarettes are an increasingly popular alternate nicotine delivery system, but nothing is known about the effects of electronic cigarettes on the lungs. We hypothesize that e-cigarettes disorder air...
Detailed Description
The specific aim of this study is to assess the hypothesis that electronic smoking disorders the biology of the airway epithelium and alveolar macrophages, to evaluate these changes in the lungs of no...
Eligibility Criteria
Inclusion
- Males and females, age 21 or older
- Must be capable of providing informed consent
- Self-reported never-smokers, with current smoking status validated by the absence of nicotine metabolites in urine (nicotine \<2 ng/ml and cotinine \<5 ng/ml)
- Normal physical examination
- Good overall health without history of chronic lung disease, including asthma, and without recurrent or recent (within 3 months) acute pulmonary disease
- Normal routine laboratory evaluation, including general hematologic studies, general serologic/immunologic studies, general biochemical analyses, and urine analysis
- Not taking any medications relevant to lung disease or having an effect on the airway epithelium
- Negative HIV serology
- Normal chest X-ray (PA and lateral)
- Normal electrocardiogram (sinus bradycardia, premature atrial contractions are permissible)
- Females - not pregnant
- No history of allergies to medications to be used in the bronchoscopy procedure
- Willingness to participate in the study
Exclusion
- Unable to meet the inclusion criteria
- Current active infection or acute illness of any kind
- Evidence of malignancy within the past 5 years
- Current alcohol or drug abuse
- Pregnancy
Key Trial Info
Start Date :
January 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2018
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT02188511
Start Date
January 1 2014
End Date
July 1 2018
Last Update
July 24 2020
Active Locations (1)
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1
Weill Cornell Medical College
New York, New York, United States, 10065