Status:
COMPLETED
Radiotherapy of Motor Deficits From Metastatic Epidural Spinal Cord Compression
Lead Sponsor:
Prof. Dirk Rades, MD
Conditions:
Metastatic Epidural Spinal Cord Compression
Eligibility:
All Genders
18-89 years
Phase:
NA
Brief Summary
The primary aim of this randomized multi-center trial is to investigate the efficacy of the radiotherapy regimens 5 x 4 Gy and 10 x 3 Gy with respect to the effect on motor function in patients with m...
Detailed Description
The primary aim of this randomized multi-center trial is to investigate the efficacy of the radiotherapy regimens 5 x 4 Gy and 10 x 3 Gy with respect to the effect on motor function in patients with m...
Eligibility Criteria
Inclusion
- Motor deficits of the lower extremities resulting from metastatic epidural spinal cord compression, which have persisted for no longer than 30 days
- Confirmation of diagnosis by magnetic resonance imaging (spinal computed tomography allowed)
- Relatively poor survival prognosis (defined as ≤35 points on the survival score published in Cancer 2008)
- Written informed consent
Exclusion
- Prior radiotherapy or surgery of the spinal areas affected by MESCC
- History of symptomatic brain tumor or symptomatic brain metastases
- Metastases of the cervical spine only
- Other severe neurological disorders
- Pregnancy, Lactation
- Indication for decompressive surgery + stabilization of the affected spinal areas
Key Trial Info
Start Date :
July 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2015
Estimated Enrollment :
203 Patients enrolled
Trial Details
Trial ID
NCT02189473
Start Date
July 1 2010
End Date
July 1 2015
Last Update
March 5 2020
Active Locations (15)
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1
Mayo Clinic
Scottsdale, Arizona, United States, 85259
2
Oberschwabenklinik Ravensburg
Ravensburg, Baden-Wutemberg, Germany, 88191
3
Klinikum Bayreuth
Bayreuth, Bavaria, Germany, 95445
4
University of Regensburg
Regensburg, Bavaria, Germany, 93053