Status:
RECRUITING
Pathogenesis and Genetics of Disseminated or Refractory Coccidioidomycosis
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Collaborating Sponsors:
University of Arizona
Conditions:
Coccidioidomycosis
Eligibility:
All Genders
2-100 years
Brief Summary
Background: \- Coccidioidomycosis is caused by a fungus that grows in the southwest United States and parts of Mexico and South America. This disease is caused by breathing dust containing the fungus...
Detailed Description
Coccidioidomycosis (CM) is a fungal disease endemic to the southwestern United States, Northern Mexico, and parts of South America. About 150,000 CM infections are estimated to occur in the United Sta...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- To be eligible for this study, potential participants must meet the following criteria:
- Age greater than or equal to 2 years old.
- a. Enrollment of pediatric patients who are acutely ill or likely to become acutely ill will be deferred until a time when they are considered medically stable by the PI.
- Have a positive Coccidioides antigen load or culture proven (a) refractory pulmonary coccidioidomycosis or (b) disseminated coccidioidomycosis.
- Refractory pulmonary coccidioidomycosis must have occurred for at least 6 months and includes progressive pulmonary involvement without significant pulmonary cavitation.
- Disseminated CM is coccidioidomycosis infection in one or more regions outside of the chest.
- Agree to undergo genetic testing.
- Allow their samples to be stored for future research.
- EXCLUSION CRITERIA:
- HIV infection
- Currently taking more than 20 mg/day of prednisone or undergoing active immunosuppressive therapy in the opinion of the investigator
- Any medical, psychiatric, social condition, occupational reason or other responsibility that, in the judgment of the investigator, is a contraindication to protocol participation or impairs a volunteer s ability to give informed consent.
Exclusion
Key Trial Info
Start Date :
September 2 2014
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 31 2029
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT02190266
Start Date
September 2 2014
End Date
July 31 2029
Last Update
January 5 2026
Active Locations (1)
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1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892