Status:
COMPLETED
Efficacy and Safety Study of Total Glucosides of Paeony Combined With Acitretin to Treat Psoriasis
Lead Sponsor:
Xijing Hospital
Collaborating Sponsors:
Henan Provincial People's Hospital
The First Affiliated Hospital of Dalian Medical University
Conditions:
Psoriasis
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This is a randomized, double blind, placebo parallel-controlled, multi-center clinical trial. Patients with psoriasis vulgaris were randomly divided into the experiment group （treated with TGP combine...
Eligibility Criteria
Inclusion
- Meet the following conditions
- Diagnosed according to Classification criteria for Psoriasis vulgaris;
- Patients aged 18 to 65 years (to the date of screening);
- PASI grade\>7point\<20 point;
- Not treatment in the Topical corticosteroids、Immunosuppresso、Biologicals agents or Tretinoin cream、Phototherapy nearly one months before enrolled.
- Understanding the whole process of the study, voluntary participation and signed the informed consent;
- Patient compliance is good, can guarantee in course of observation.
Exclusion
- One of the following is not included in this study:
- Pregnant women, ready to pregnant or lactating women;
- Known to root of herbaceous peony total glycosides (TGP) drug allergy;
- Have a serious heart, lung, kidney and other vital organs and endocrine system lesions and the history
- Patients is liver function abnormal persons (ALT above the center laboratory normal limit) or hepatitis b patient grain carriers;
- Need insulin control of diabetes; High blood pressure did not get good controller ;
- Patients with white blood cells \<4.0 × 109 / L, or a definite anemia (hemoglobin less than 100g / L), or platelets \<100 × 109 / L, or other blood disease;
- Patients with chronic diarrhea, or peptic ulcer nearly 1 year;
- Patients suffering from malignant tumor;
- Patients suffering from acute and chronic infectious diseases;
- Mental disorders, history of alcohol abuse, drug or other substance abuse; 11. Other cases which researchers believe that can not enroll.
Key Trial Info
Start Date :
February 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2013
Estimated Enrollment :
108 Patients enrolled
Trial Details
Trial ID
NCT02191020
Start Date
February 1 2013
End Date
October 1 2013
Last Update
July 15 2014
Active Locations (1)
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1
Xijing Hospitial
Xi'an, Shaanxi, China, 710032