Status:
COMPLETED
Effect of Anesthetics on Oxygenation and Microcirculation During One-lung Ventilation
Lead Sponsor:
Seoul National University Hospital
Conditions:
Mechanical Ventilation Complication
Eligibility:
All Genders
20-90 years
Phase:
NA
Brief Summary
One-lung ventilation during thoracic surgery may affect systemic oxygenation and peripheral microcirculation by hypoxic pulmonary vasoconstriction. Both intravenous and inhalational anesthetics can be...
Detailed Description
Patients undergoing thoracic surgery including one-lung ventilation will be randomized to receive intravenous (propofol) or inhalational (desflurane) anesthetic. Systemic oxygenation can be evaluated...
Eligibility Criteria
Inclusion
- undergoing thoracic surgery including one-lung ventilation
Exclusion
- refuse to enroll
- BMI over 30 kg/m(2)
- severe obstructive or restrictive lung disease
- preoperative supplemental oxygen, intubated, or mechanical ventilatory support
- preoperative arterial partial pressure of oxygen \< 60 mmHg
- pregnancy
- history of coronary artery disease
- preoperative continuous infusion of vasopressor or inotropes
- cannot undergo vascular occlusion test: anatomical abnormality of both arms, severe peripheral vascular disease, presence of A-V fistula
Key Trial Info
Start Date :
July 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
104 Patients enrolled
Trial Details
Trial ID
NCT02191371
Start Date
July 1 2014
End Date
December 1 2014
Last Update
October 13 2016
Active Locations (1)
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1
Seoul National University Hospital
Seoul, South Korea, 110-744