Status:
COMPLETED
Chronic Effects of Natural and Interesterified Fats Margarine on Insulin Sensitivity and Selected Markers of Cardiovascular Diseases (CVD)
Lead Sponsor:
Malaysia Palm Oil Board
Collaborating Sponsors:
IMU University, Malaysia
Universiti Putra Malaysia
Conditions:
Overweight
Eligibility:
All Genders
20-60 years
Phase:
NA
Brief Summary
The investigators hypothesized that there will be a significant difference between the effects of trans-free palm-, interesterified palm- and interesterified soybean oil blend on cardiovascular diseas...
Detailed Description
Human volunteers will be conditioned for a 8 wk intervention on 3 different test diets providing 30 % energy as fat, 15% energy as protein and 55% energy as carbohydrate according to parallel designed...
Eligibility Criteria
Inclusion
- Adult males and females, aged 20-60 yr
- Staff and students of International Medical University, IMU/ Staff of Malaysian Palm Oil Board, MPOB to facilitate centralized consumption of the test fats/snacks
- BMI 21 - 30 kg/m2
Exclusion
- Abnomal liver function test (elevated transaminases- alanine aminotransferase,ALT; aspartate aminotransferase,AST))/ abnormal kidney function test (elevated plasma creatinine)
- History of type 2 diabetes mellitus, cancer, stomach ulcers, drug abuse or alcoholism
- Smokers
- On lipid/blood pressure- lowering medication/supplements
- Blood pressure\>140/90 mmHg
- Fasting total cholesterol \> 6.5 mmol/L
- Fasting TAG \> 2.0 mmol/L
- Candidates who are going abroad during the planned schedule for the dietary intervention
Key Trial Info
Start Date :
September 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2014
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT02192047
Start Date
September 1 2012
End Date
March 1 2014
Last Update
July 16 2014
Active Locations (1)
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1
University Putra Malaysia
Serdang, Selangor, Malaysia, 43400