Status:
COMPLETED
Use of Dexamethasone in Pediatric Asthma Exacerbations
Lead Sponsor:
University at Buffalo
Conditions:
Asthma
Eligibility:
All Genders
2-20 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to compare the efficacy of a single dose of dexamethasone vs. two doses of dexamethasone in mild and moderate asthma exacerbations pediatric patients.
Detailed Description
The emergency department (ED) physician will follow the standard asthma care path to manage a pediatric asthma patient whether the patient meets study criteria or not. Patients' legal guardian will be...
Eligibility Criteria
Inclusion
- Children aged 2 to 20 years, from all race and ethnicity groups, with a known history of asthma who present to the Emergency Department of Women and Children's Hospital of Buffalo with an acute exacerbation of mild or moderate asthma are potentially eligible for the study. Patients with severe asthma exacerbations will require intravenous steroid therapy, therefore, they will not be enrolled in the study. The investigators plan to enroll patients from winter of 2014 to fall 2016.
- History of asthma is defined by physician diagnosis of at least 1 prior episode of wheezing which responded to beta agonist medication.
- Mild asthma is defined as: Pediatric Asthma Score (PAS) of 5 to 7; Moderate asthma is defined as: PAS of 8 to 11; Severe asthma is defined as: PAS of 12 or more.
Exclusion
- Children who have one of the following conditions will be excluded from the study: are less than 2 years of age, have signs of severe exacerbation (Pediatric Asthma Score of more than 11), have used oral steroids in the last 2 weeks, have chronic lung disease (e.g., cystic fibrosis), have been given IV solumedrol, or vomit two doses of dexamethasone in emergency department.
Key Trial Info
Start Date :
April 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2018
Estimated Enrollment :
318 Patients enrolled
Trial Details
Trial ID
NCT02192827
Start Date
April 1 2015
End Date
March 1 2018
Last Update
March 30 2023
Active Locations (1)
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1
Women and Children's Hospital Of Buffalo
Buffalo, New York, United States, 14222