Status:
COMPLETED
Feasibility of Generating Pluripotent Stem Cells From Patients With Familial Retinoblastoma
Lead Sponsor:
St. Jude Children's Research Hospital
Collaborating Sponsors:
University of Wisconsin, Madison
Conditions:
Retinoblastoma
Eligibility:
All Genders
Brief Summary
The goal of this study is to determine if human RB1-deficient induced pluripotent stem cells (iPSCs) can produce retina, and, furthermore, can give rise to retinoblastoma in culture. This unique oppor...
Detailed Description
This is an observational study where a small skin cell sample or peripheral blood sample will be used to produce iPSCs. After RB1-deficient iPSCs are produced, their karyotype and RB1 mutation will be...
Eligibility Criteria
Inclusion
- Research participant with heritable retinoblastoma and one of the following criteria:
- Family history with RB1 mutation identified
- Diagnosis of bilateral retinoblastoma
- Diagnosis of unilateral retinoblastoma with RB1 mutation or MYCN amplification identified
- Participant or legal guardian/representative is able and willing to provide written informed consent.
Exclusion
- Participants who do not meet the inclusion criteria will be excluded.
Key Trial Info
Start Date :
November 4 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 23 2019
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT02193724
Start Date
November 4 2014
End Date
August 23 2019
Last Update
October 23 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
St. Jude Children's Research Hospital
Memphis, Tennessee, United States, 38105