Status:
COMPLETED
The Belly Fat Study: Nutritional Intervention to Improve Metabolic Health in Subjects With Increased Abdominal Adiposity
Lead Sponsor:
Wageningen University
Conditions:
Abdominal Obesity
Liver Fat
Eligibility:
All Genders
40-70 years
Phase:
NA
Brief Summary
In the Belly Fat study, the effects of two different caloric-restricted diets on metabolic health will be examined in male and female subjects with increased abdominal adiposity (BMI \>27 kg/m2). Meta...
Detailed Description
Rationale: It is known that in particular visceral fat (abdominal obesity) and fat deposition in non-adipose tissue such as the liver are important factors related to metabolic health, such as the deg...
Eligibility Criteria
Inclusion
- Age 40-70y at the time of recruitment
- BMI \>27kg/m2 or waist circumference \>102cm (males) or \>88cm (females)
Exclusion
- Diabetic (normoglycemic according to WHO criteria (OGTT, fasting blood glucose\< 7 mmol/L, after 2 hr \<11.1 mmol/L)
- Daily intake of alcohol of \>30g (men) or \>20g (women)
- Tobacco smoker
- Abuse of drugs
- Any medical conditions or (metal) devices interfering with or posing a risk for the participant in 1H-MRS/MRI scanning (e.g. claustrophobia, pace maker, surgical screws/pins, artificial joints or heart valves, etc.)
- Diagnosed with any long-term medical condition (i.e. cardiovascular disease, gastrointestinal disease, renal dysfunction)
- Use of medications known to interfere with glucose or lipid homeostasis (i.e. corticosteroids)
- Allergic to fish oil or unwilling to consume fish oil supplements
- Unwilling to comply with dietary guidelines
- Restricted to a vegetarian dietary regime
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 1 2015
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT02194504
Start Date
September 1 2014
End Date
March 1 2015
Last Update
April 17 2015
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