Status:
COMPLETED
Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver.
Lead Sponsor:
Yale University
Collaborating Sponsors:
National Institute on Aging (NIA)
Conditions:
Insulin Resistance
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
The purpose of this study was to examine the pathophysiology of insulin resistance and the relation to the metabolic syndrome in humans.
Detailed Description
In this study insulin resistant (IR), young offspring of parents with type 2 diabetes (18-46 years) and healthy, lean elderly individuals (65-90 years) underwent 1H/13C MRS measurements of liver and m...
Eligibility Criteria
Inclusion
- Body Mass Index \< 29 kg/m2
- No regular exercise routine
- Non-smokers
- Absence of systemic and organ disease.
Exclusion
- Hematocrit \< 35 vol%
- History of claustrophobia
- Ferromagnetic implants
- Regular exercise regimen
- Not weight stable
- Any significant hematological, neurological, musculoskeletal or endocrine disease (including diabetes mellitus)
- Any significant cardiovascular condition, including confirmed CAD and prior cardiovascular events
- Taking coumadin as anticoagulant therapy.
Key Trial Info
Start Date :
January 1 2008
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 30 2012
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT02196051
Start Date
January 1 2008
End Date
January 30 2012
Last Update
August 15 2024
Active Locations (1)
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1
YCCI/YNNH Hospital Research Unit
New Haven, Connecticut, United States, 06520