Status:
COMPLETED
Acute Effects of Cortisol on Alcohol Craving in Alcohol Dependence
Lead Sponsor:
Insel Gruppe AG, University Hospital Bern
Conditions:
Alcohol Craving
Psychological Stress
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
To investigate the effects of cortisol on alcohol craving and stress reactivity in alcohol addicted subjects. Randomized, double-blind, placebo-controlled, cross-over, single administration of study ...
Detailed Description
Background Alcohol dependence is a chronically and relapsing disorder with major impact on the persons psychological, physiological and social functioning. There is extensive evidence from animal and...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Age ≥ 18
- Abstinent alcoholics in the 12-week in-patient program of the Clinic Südhang
- Abstained from alcohol for at least 6 weeks
- Voluntarily signed informed consent
- Exclusion Criteria
- Co-morbid psychiatric disturbances (such as major depression, bipolar disorder, schizophrenia)
- Current medical conditions excluding participation (such as acute infectious disease)
- Recent history of systemic or topic glucocorticoid therapy
- Known hypersensitivity to the IMP under investigation (cortisol)
- Pregnancy, breast-feeding
- Inability to read and understand the participant's information
- Positive alcohol test according to breathalyser
Exclusion
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2015
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT02196142
Start Date
November 1 2014
End Date
June 1 2015
Last Update
June 24 2015
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Klinik Südhang
Kirchlindach, Canton of Bern, Switzerland, CH-3038