Status:
COMPLETED
Pilot Study of Atorvastatin for Orthopedic Surgery Patients
Lead Sponsor:
Hospital for Special Surgery, New York
Collaborating Sponsors:
Weill Medical College of Cornell University
Washington University School of Medicine
Conditions:
Hip Fracture
Myocardial Ischemia
Eligibility:
All Genders
65-99 years
Phase:
PHASE2
Brief Summary
Up to 35% of hip fracture patients have been shown to experience heart injury after surgery, and as many as 10% have a heart attack or die in the three months after surgery. Hip and knee arthroplasty ...
Detailed Description
* Thirty statin-naïve patients ≥ 65 years of age admitted to New York Presbyterian Hospital or Hospital for Special Surgery with an acute hip fracture, or for elective hip or knee arthroplasty will be...
Eligibility Criteria
Inclusion
- Hip fracture or elective hip or knee arthroplasty
- Age 65 years or older
- Life expectancy \> 3 months
Exclusion
- Pathological hip fracture due to cancer
- Currently taking a statin, or took a statin within the last 30 days
- Previous statin intolerance
- Acute myocardial infarction or unstable angina
- History of myocardial infarction, acute coronary syndrome, angina, coronary/arterial re-vascularization
- Hip fracture patients with peripheral arterial disease
- Hip fracture patients with history of stroke or transient ischemic attack.
- Muscle disorder
- Serious liver disease or alanine aminotransferase \> 3x upper limit of normal
- Serious renal disease (creatinine clearance \<30cc/min)
- Treatment with HIV protease inhibitor or Hepatitis C protease inhibitor
- Treatment with erythromycin, clarithromycin, niacin or azole antifungal agent
- Pregnant, planning to become pregnant, or breastfeeding
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2017
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT02197065
Start Date
September 1 2014
End Date
January 1 2017
Last Update
July 2 2017
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Hospital for Special Surgery
New York, New York, United States, 10021
2
New York Presbyterian Hospital (Cornell)
New York, New York, United States, 10065