Status:
COMPLETED
A Comparison of Efficacy of Intravenous Esomeprazole and Ranitidine Treatment of Dyspeptic Pain
Lead Sponsor:
Pamukkale University
Conditions:
Dyspepsia
Eligibility:
All Genders
18-60 years
Phase:
PHASE4
Brief Summary
* Currently, Proton Pump Inhibitors and H2Receptor Blockers are widely used by emergency physicians in Turkey for the treatment of patients with dyspepsia. * The objective of the study was to assess w...
Detailed Description
* this is the placebo randomized double blinded clinical trial to compare the efficacy of these three drugs in this clinical setting. * A randomized clinical trial was conducted in the ED of Pamukkale...
Eligibility Criteria
Inclusion
- patients were eligible for inclusion if they were aged 18 years or older, 60 years or older,
- had dyspspsia \[VAS (visual analog scale) score \>5\] during their ED episode of care for which the attending physician recommended medication.
Exclusion
- pretreatment 100-mm linear visual analog scale (VAS) pain score less than 50 mm;
- known cases of malignancy or terminal illness;
- known cases of major medical problems (eg, any evidence of active structural or functional abnormality of the hearts, chronic renal failure)
- allergy or previous adverse reaction to study drugs studied
- received agents to inhibit the secretion of acid (PPIs or histamine-2 receptor antagonists), nonsteroidal anti-inflammatory drugs,
- who consumed alcohol within 4 hours before the ED visit
- diarrhea more than 2 times within the past 24 hours;
- being suspected to have other ED diagnoses (eg, gut obstruction, biliary colic, pancreatitis, hepatitis, or localized hepatobiliary infections);
- being pregnant or breast-feeding; and
- inability to comprehend the VAS evaluation.
- and patients who refused to participate study.
Key Trial Info
Start Date :
March 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2014
Estimated Enrollment :
286 Patients enrolled
Trial Details
Trial ID
NCT02197143
Start Date
March 1 2013
End Date
July 1 2014
Last Update
July 22 2014
Active Locations (1)
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1
Pamukkale Universty
Denizli, Denizli, Turkey (Türkiye), 20000