Status:
COMPLETED
A RCT Comparing Spontaneous Natural Cycles and Human Chorionic Gonadotrophin-induced Natural Cycles in FET
Lead Sponsor:
The University of Hong Kong
Conditions:
Subfertility
Pregnancy
Eligibility:
FEMALE
18-43 years
Phase:
NA
Brief Summary
This is a randomized controlled trial on the comparison of the ongoing pregnancy rate in frozen-thawed embryo transfer cycles with spontaneous ovulation and hCG-induced natural cycles.
Detailed Description
Embryo cryopreservation is essential nowadays. It allows the usage of surplus good quality embryos in frozen-thawed embryo transfer (FET) cycles which avoids embryo wastage and facilitates the adoptio...
Eligibility Criteria
Inclusion
- Age of women \<43 years
- Regular menstrual cycles ranging from 21-35 days with not more than 4 days variation between cycles
- Undergoing FET in natural cycles
- Normal uterine cavity as shown on saline sonogram performed before the IVF cycle or normal uterine cavity shown on pelvic scanning during the stimulated IVF cycle
- Endometrial thickness \>=8mm in both stimulated IVF and FET cycles
Exclusion
- \>3 previous IVF cycles
- \>6 embryos replaced without pregnancy
- Irregular menstrual cycles
- Subjects requiring clomid-induced cycles and hormonal replacement (HRT) cycles
- History of previous FET cycles within the study period
- Blastocyst transfer
- Preimplantation genetic diagnosis treatment
- Use of donor oocytes
- Presence of hydrosalpinx not corrected surgically prior to FET
- Recurrent miscarriage
- Serum progesterone level on the day of LH surge or day of hCG \>5 nmol/L or 1.5 pg/L (these patients will be retrospectively excluded)
- Refusal to join the study
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2015
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT02197208
Start Date
October 1 2014
End Date
December 1 2015
Last Update
December 11 2015
Active Locations (2)
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1
Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University
Guangzhou, China
2
Queen Mary Hospital
Hong Kong, Hong Kong, Hong Kong, 852