Status:
COMPLETED
Preliminary Evaluation of Septin9 in Patients With Hereditary Colon Cancer Syndromes
Lead Sponsor:
University of Pennsylvania
Collaborating Sponsors:
Epigenomics, Inc
Conditions:
Familial Adenomatous Polyposis
Map Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
This is an observational, case-control study evaluating the quantitative level of Septin9 in plasma pre- and post-colectomy in hereditary colorectal cancer (CRC) syndrome patients (Familial Adenomatou...
Eligibility Criteria
Inclusion
- Informed consent provided
- Age \> or = to 18 years of age
- Patient group FAP
- \- Clinical diagnosis of familial adenomatous polyposis
- Patient group Lynch syndrome Clinical diagnosis of Lynch syndrome
- Patient group MAP
- \- Clinical diagnosis of MYH-associated polyposis and presence of more than 20 colon polyps
- Control group (FAP)
- \- Genetically related family member of patient
- Patients: Able and willing to attend routine follow-up as advised
- Controls, i.e. relatives of patients: Willingness to give blood at each routine follow-up as advised for the diseased relative
Exclusion
- Known infection with Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), or Hepatitis C Virus (HCV)
- Current diagnosis of colorectal cancer
- Pregnancy
Key Trial Info
Start Date :
July 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2019
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT02198092
Start Date
July 1 2014
End Date
August 1 2019
Last Update
August 28 2019
Active Locations (1)
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1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104