Status:
COMPLETED
Comparison of MEOPA + Paracetamol Versus Morphine Treatment in Acute Coronary Syndrome Analgesia.
Lead Sponsor:
University Hospital, Toulouse
Conditions:
Acute Coronary Syndrome
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
In the management of acute coronary syndromes with ST-segment elevation (STEMI), early analgesia reduces the effects of hyperadrenalism which increases the size of myocardial infarction. In order to r...
Detailed Description
The investigators wish to compare the use of morphine according to current recommendations with the use of MEOPA associated with intravenous paracetamol in the management of patients with STEMI. The i...
Eligibility Criteria
Inclusion
- Patient with STEMI \< 12 h treated before hospital admission and pain ≥ 4 on the numerical rating scale.
Exclusion
- Acute severe hemodynamic, respiratory or neurological failure
- Heart failure: Killip class III and IV
- Known allergy to morphine or nitrous oxide
- Patient who has already received morphine or MEOPA before the arrival of the hospital team during the 4 hours preceding the pre-hospital intervention
- Contraindications to nitrous oxide
- Patient unable to assess pain intensity on the numerical rating scale
- Patient under legal guardianship
- Pregnancy
- Patient transported by air ambulance
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2017
Estimated Enrollment :
680 Patients enrolled
Trial Details
Trial ID
NCT02198378
Start Date
November 1 2014
End Date
January 1 2017
Last Update
February 5 2018
Active Locations (40)
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1
Centre Hospitalier d'Agen
Agen, France
2
Centre Hospitalier Jean Minjoz
Besançon, France
3
CHU Avicenne
Bobigny, France
4
Hôpital Pellegrin
Bordeaux, France