Status:
UNKNOWN
Clomiphene Citrate Plus Gonadotropins and GnRH Antagonist Versus Flexible GnRH Antagonist Protocol Versus Microdose GnRH Agonist Protocol in Poor Responders Undergoing IVF
Lead Sponsor:
Bioroma
Conditions:
Poor Responders
IVF
Eligibility:
FEMALE
25-44 years
Phase:
PHASE4
Brief Summary
Poor ovarian response to stimulation in IVF cycles is a challenging and frustrating condition, due to its poor prognosis in terms of chances of pregnancy and live births. Various ovarian stimulation r...
Eligibility Criteria
Inclusion
- poor responders in a previous IVF cycle at least 3 months before at our center and undergoing a new IVF attempt with at least two of the following criteria : I) age \> 40 years old; II) basal follicular stimulation hormone (FSH) \> 12 mIU/ml; III) three or fewer oocytes retrieved in the previous IVF cycle; IV) low estradiol levels on the day of human chorionic gonadotropin (hCG) administration (\< 1500 pmol/ml).
Exclusion
- body mass index \> 30
- biochemical and ultrasound evidence of polycystic ovary syndrome
- stage III-IV endometriosis
- inflammatory or autoimmune disorders
- metabolic disease
- infertility medications within the past two months
Key Trial Info
Start Date :
January 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 1 2014
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT02201914
Start Date
January 1 2014
End Date
November 1 2014
Last Update
July 28 2014
Active Locations (1)
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1
Bioroma
Rome, Rome, Italy, 00197