Status:
COMPLETED
Prospective Multicenter Study on the Identification of Genetic Abnormalities Predisposing to Vasospasm From a Privileged Model: the Primary Raynaud's Phenomenon
Lead Sponsor:
Nantes University Hospital
Conditions:
Primary Raynaud's Phenomenon (PR)
Genetic Mutations Causing PR
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Vasospasm is a transient contraction causing a decrease in caliber of a vessel and thus a decrease in vascularization in a vascular territory leading to suffering of tissue in the sector concerned. Va...
Detailed Description
Patients with primary Raynaud phenomenon will be identified during a consultation of vascular medicine and internal medicine in one of the centers participating to the study. Those patients with a pri...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Major Subject (age ≥ 18 years)
- Index case with all the diagnostic criteria for primary Raynaud phenomenon, according to current recommendations OR Related index case (relatives' patients) with or without a primary Raynaud phenomenon.
- Written consent to participate in the study
- Written consent to participate in the collection of biological samples
- Exclusion criteria:
- Subjects who have expressed their inability or refusal to sign an informed consent,
- Index case with a secondary Raynaud phenomenon (suspected by clinical examination and confirmed by capillaroscopy and laboratory tests: antinuclear antibody, abnormalities of capillaroscopy mégacapillaire dystrophy or other major deviation).
- (Criterion not applicable to related parties, i.e. family members of Index cases)
- \- Pregnant Woman.
Exclusion
Key Trial Info
Start Date :
October 13 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 10 2020
Estimated Enrollment :
258 Patients enrolled
Trial Details
Trial ID
NCT02202291
Start Date
October 13 2014
End Date
June 10 2020
Last Update
June 24 2020
Active Locations (6)
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1
CHU Angers - Service d'Explorations vasculaires
Angers, France, 49033 Angers Cedex 01
2
CHRU HOPITAL CAVALE BLANCHE - Service de Médecine vasculaire
Brest, France, 29609 Brest Cedex 2
3
CHD La Roche sur Yon - Service Angéiologie
La Roche-sur-Yon, France, 85925 La Roche/Yon Cedex 9
4
CHU de NANTES - Service de Médecine Interne
Nantes, France, 44000