Status:
COMPLETED
Effects of Korean Red Ginseng on Male Infertility
Lead Sponsor:
Pusan National University Hospital
Conditions:
Male Infertility
Eligibility:
MALE
25-45 years
Phase:
PHASE4
Brief Summary
Objective: Several in vitro studies report positive effects of ginseng on spermatogenesis. However, no controlled human clinical study of the effect of Korean red ginseng (KRG) on spermatogenesis has ...
Eligibility Criteria
Inclusion
- Patients should be males, 25 - 45 years of age
- Complained of infertility for at least 12 months
- No history of surgical or medical treatments for infertility
- Increased retrograde flow in the internal spermatic vein with venous diameter \> 3 mm during the Valsalva maneuver on scrotal ultrasonography was used as an indicator of varicocele.13 Varicocele was graded according to the criteria presented by Lyon et al.14: grade I, palpable only with the Valsalva maneuver; Grade II, palpable without the Valsalva maneuver; Grade III, visible from a distance.
Exclusion
- The exclusion criteria were as follows:
- A history of vasectomy or obstructive azoospermia
- Chromosomal abnormalities
- Hypogonadism or pituitary abnormalities
- Anatomical abnormality of the genitals
- Significant hepatopathy (liver enzymes elevated 2 - 3-fold higher than the normal range)
- Renal insufficiency (serum creatinine level \> 2.5 mg/dL)
- Medical treatment for infertility during the past 4 weeks
Key Trial Info
Start Date :
April 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT02202382
Start Date
April 1 2011
Last Update
July 31 2014
Active Locations (1)
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1
Department of Urology, Pusan National University Hospital
Busan, South Korea, 602-739