Status:
UNKNOWN
Investigation of the Blood-brain and Blood-dura Barrier Durin Migraine Attacks Using MRI
Lead Sponsor:
Glostrup University Hospital, Copenhagen
Conditions:
Migraine With Aura
Migraine Without Aura
Eligibility:
All Genders
18-80 years
Brief Summary
Substudy 1 Blood-brain barrier breakdown has been proposed in migraine patients. Our hypothesis that we will test in this study is that the blood-brain barrier breaks down during migraine attacks but ...
Detailed Description
Brain MRI during and outside migraine attacks. Up to 600 patients will be recruited, who will be given a phone number that they can call when they get migraine attacks. The study will continue until...
Eligibility Criteria
Inclusion
- diagnosis of migraine with aura, migraine without aura, or chronic migraine according to the International Headache Society.
- written informed consent.
- use of anticonceptive method by women in childbearing age.
Exclusion
- tension type headache more than 5/month during last year.
- tension type headache on the experimental day.
- use of antimigraine medication or pain-killer on the experimental day before MRI.
- pregnant or breastfeeding women.
- contraindications against MRI.
- history or clinical sign of cardio- or cerebrovascular disease.
- untreated severe mental disorder or drug abuse.
- other diseases or disorders interpreted, by the examining doctor, to interfere with participation in the study.
- not accepting information about potential accidental finding during experiment.
Key Trial Info
Start Date :
September 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2015
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT02202486
Start Date
September 1 2012
End Date
December 1 2015
Last Update
July 29 2014
Active Locations (1)
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1
Danish Headache Center, Glostrup Hospital
Glostrup Municipality, Copenhagen, Denmark, 2600