Status:
COMPLETED
Effect of Repeated Doses of BI 1060469 and BI 1021958 on Glomerular Filtration Rate (GFR) in Healthy Volunteers
Lead Sponsor:
Boehringer Ingelheim
Conditions:
Healthy
Eligibility:
MALE
18-40 years
Phase:
PHASE1
Brief Summary
Main objective is to investigate the measured glomerular filtration rate (mGFR) as assessed by iohexol clearance in healthy male normovolemic subjects after oral administration of single and repeated ...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Healthy male subjects according to the investigators assessment, as based on the following criteria: a complete medical history including a physical examination, vital signs (blood pressure (BP), pulse rate (PR)), 12-lead electrocardiogram (ECG), and clinical laboratory tests, including negative test result on occult blood in stool (only for subjects assigned to Naproxen)
- Age 18 to 45 years (incl.)
- Body Mass Index (BMI) 18.5 to 29.9 kg/m2 (incl.)
- Signed and dated written informed consent prior to admission to the study in accordance with good clinical practice (GCP) and local legislation
- Exclusion criteria:
- Any finding in the medical examination (including BP, PR or ECG) deviating from normal and judged clinically relevant by the investigator
- Repeated measurement of systolic blood pressure greater than 140 mm Hg, diastolic blood pressure greater than 90 mm Hg, or pulse rate outside the range of 50 to 90 mmHg
- Any laboratory value outside the reference range that the investigator considers to be of clinical relevance
- Serum creatinine laboratory value out of the normal range
- GFR (Glomerular Filtration Rate) \< 90 mL/ min at screening
- Urinary toral protein/creatinine ratio \> 0,1 mg protein/ mg creatinine
- Current or history of relevant kidney, urinary tract diseases or abnormalities (i.e. nephrolithiasis, hydronephrosis, acute or chronic nephritis, renal injury, renal failure, infections)
- Further exclusion criteria may apply
Exclusion
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT02202512
Start Date
September 1 2014
End Date
December 1 2014
Last Update
December 24 2014
Active Locations (1)
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1
1333.43.1 Boehringer Ingelheim Investigational Site
Berlin, Germany