Status:
COMPLETED
The Significance of Urine UbA52 In the Diagnosis of Diabetic Nephropathy
Lead Sponsor:
Hebei Medical University Third Hospital
Collaborating Sponsors:
Sixth Affiliated Hospital, Sun Yat-sen University
Conditions:
Diabetic Nephropathy
Eligibility:
All Genders
18-70 years
Brief Summary
Definite diagnosis of diabetic nephropathy is currently based on renal biopsy findings. In most cases, however, the diagnosis can be reliably made in patients with macroalbuminuria in the presence of ...
Detailed Description
It is now well recognized that the incidence of diabetes is increasing worldwide. It is the leading cause of end-stage renal disease (ESRD) in Western countries. Diabetic nephropathy has been reported...
Eligibility Criteria
Inclusion
- diabetes diagnostic criteria (WHO, 1999),age \< 80 years old, gender not limited;
- diabetic with macro-or microalbuminuria;
- the subjects not took hemodialysis;
- with proteinuria due to nondiabetic renal disease :Hypertensive renal damage,drug-induced acute interstitial nephritis, IgA, primary membranous nephropathy,FSGS or MCD, which were confirmed by renal biopsy.
Exclusion
- acute diabetic complications: ketoacidosis, hypertonic coma;
- the diagnosis of malignant tumors, particularly affecting the liver and kidney function of tumor and the application of radiation and chemotherapy treatment of patients;
- cardiac insufficiency, heart function class 3 or above;
- data is not complete, have an impact on the results;
- not hospitalized patients;
- accept long-term oral or static point methods such as steroid hormone therapy, application of renal toxicity of drugs;
- with the exception of primary kidney disease and other causes lead to eye disease;
- the combination of respiratory system infection or other systemic diseases and patients with severe primary diseases, vigorous exercise within 24 hours;
- pregnancy or breastfeeding women
- there is a clear liver disease, its alanine or aspertate aminotransferase 2 times higher than normal limit;
- reluctant to collaborators and psychiatric patients;
- has been undergoing hemodialysis.
Key Trial Info
Start Date :
August 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2015
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT02204280
Start Date
August 1 2014
End Date
July 1 2015
Last Update
July 21 2015
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